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Generalization of Tetris: A strategic game with a variety of morphing shapes flowing through topological holes (like digestive tract) with increasing variety and speed, and complementaries (like matching Tetris bricks) that interact to break down into smaller ones, and a global goal to sustain their flow from clogging the system.
想法 Movable Frame Tetris
Instead of moving the falling brick, move the entire tetris frame in the rain of tetris parts; make the frame walls semi-permeable sometimes, and emulate life form eating bricks, and medical interventions to alleviate clogging.